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This group will focus on the research of molecular alterations potentially involved in the pathogenesis of chronic myeloproliferative neoplasms through innovative analytical technologies which allow the study of DNA sequence, RNA and micro RNA expression and mechanisms of gene expression regulation. These results can lead to the identification of new diagnostic and prognostic markers and new therapeutic targets. The bioinformatic analysis required to process the experimental data obtained will be carried out with the collaboration of the bioinformatic group of Biology Department of University of Padova, under the supervision of Dr S. Bortoluzzi. Finally, the organization of pharmacological trial , involving all the AGIMM groups with clinical activity, will be assured thanks to the support of the Laboratory of Clinical Epidemiology for cardiovascular diseases of Mario Negri Sud Institute, directed by Dr. R. Marchioli.
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